Glutathione S-transferase polymorphisms and risk of ovarian cancer: A HuGE review
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چکیده
منابع مشابه
Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review.
The genes glutathione S-transferase M1 (GSTM1) (chromosome 1p13.3) and glutathione S-transferase T1 (GSTT1) (22q11.2) code for cytosolic enzymes glutathione S-transferase (GST)-mu and GST-theta, respectively, which are involved in phase 2 metabolism. Both genes may be deleted. There is geographic and ethnic variation in genotype frequencies for both genes. In developed countries, colorectal can...
متن کاملIsothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk.
BACKGROUND Isothiocyanates, compounds found primarily in cruciferous vegetables, have been shown in laboratory studies to possess anticarcinogenic activity. Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates. OBJECTIVE The objective...
متن کاملGlutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk.
PURPOSE To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used ...
متن کاملPooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review.
Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in tobacco smoke; a homozygous deletion of this gene in approximately 50% of Caucasians and Asians results in a lack of GSTM1 enzyme activity. Most studies examining the relation between bladder cancer...
متن کاملHuman Genome Epidemiology (HuGE) Review Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis
1 Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 2 School of Environmental Health, University of British Columbia, Vancouver, British Columbia, Canada. 3 United Kingdom HuGENet Coordinating Centre, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom. 4 MRC Biostatistics Unit, Institute of Public H...
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ژورنال
عنوان ژورنال: Genetics in Medicine
سال: 2002
ISSN: 1098-3600,1530-0366
DOI: 10.1097/00125817-200207000-00003